Second International Workshop on Granulation 2004 - Abstracts
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چکیده
In the pharmaceutical industry high hear granulation is a commonly used process step in the production of a solid formulation. Because of regulatory guidelines and product quality assurance, an important granule requirement is homogeneity. However, often granule inhomogeneity is observed, expressed as a granule size-dependent variation in composition of the granules [1-4]. As a consequence of segregation during subsequent process steps this might introduce content uniformity problems. In order to solve these quality problems the mechanisms involved in the formation of non-homogeneous granulates have to be elucidated.
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تاریخ انتشار 2004